August, 1957. America is lost. Four years after the end of the critically-acclaimed Resistance 2, dishonorably discharged Sentinel Joseph Capelli has given up fighting the Chimeran menace. Now he's in hiding with other survivors, including his wife and young son. But when Dr. Fyodor Malikov arrives with the opportunity to deliver a blow to the occupying Chimeran force, Capelli must leave his family and journey the harrowing road from Oklahoma to New York City. Along the way, he'll encounter the remnants of humanity left in the aftermath of the brutal Chimeran invasion